Nicotine Induces Proinflammatory Responses in Macrophages and the Aorta Leading to Acceleration of Atherosclerosis in LDLR-/- Mice ONLINE SUPPLEMENT
نویسندگان
چکیده
Condensed abstract: We investigated the molecular mechanism of nicotine-accelerated atherosclerosis in hyperlipidemic LDLR-/mouse model. Our findings reveal a novel mechanism of nicotine in atherogenesis. Nicotine directly activates macrophages via the nicotinic acetylcholine receptors, inducing multiple downstream events, subsequently resulting in NFkB-mediated inflammation in the arterial wall and accelerated atherosclerosis.
منابع مشابه
Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice.
OBJECTIVE We investigated the molecular mechanism of nicotine-accelerated atherosclerosis in a hyperlipidemic low-density lipoprotein receptor(-/-) mouse model. METHODS AND RESULTS Low-density lipoprotein receptor(-/-) mice received time-release nicotine or placebo pellets for 90 days. Aortic lesion size was 2.5 times larger in nicotine-treated than in placebo-treated mice (P<0.001). A mild i...
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